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Cells from healthy individuals with major depressive disorder were found to have higher than expected rates of methylation at specific sites on their DNA, when compared to cells from healthy individuals without MDD, according to a study by a multidisciplinary team of Walter Reed Army Institute of Research and University of California San Francisco scientists, in collaboration with others.
Methylation is a process by which DNA is chemically modified at specific sites, resulting in changes in the expression of certain genes. Methylation of particular sets of genes, called DNA methylation clocks, typically change in predictable ways as people age, but the rate of these changes varies between people. Methylation patterns in individuals with MDD suggested that their DNA methylation cellular age was, on average, accelerated relative to matched healthy controls.
Accelerated Cellular Aging Associated with Mortality Seen in Depressed Individuals
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Accelerated cellular aging associated with mortality seen in depressed individuals
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Researchers from the PTSD Systems Biology Consortium, led by scientists from the Walter Reed Army Institute of Research, have identified distinct biotypes for post-traumatic stress disorder, the first of their kind for any psychological disorder. These biotypes can refine the development of screening tools and may explain the varying efficacy of PTSD treatments , said Dr. Marti Jett, leader of the consortium and WRAIR chief scientist.
Publishing their work in
Molecular Psychiatry in a manuscript first authored by WRAIR s Dr. Ruoting Yang, researchers used blood tests from male, combat-exposed veterans across a three year period to identify two PTSD biotypes, G1 characterized by mild, inherent co-morbidities typical of PTSD and G2 which includes more severe symptoms typical of PTSD and report more physical distress with differing genetic markers and underlying mechanisms of disease. Building on previously published work using machine learning, led by Dr. Francis J. Doyl