This chapter in Stan Weir's Singlejack Solidarity tells the history of how, from the victory in the 1934 General Strike through the first Mechanization & Modernization (M&M) Agreement in 1961, longshore workers in San Francisco had 27 years of near-total control of the labor process on the waterfront in the "largest, longest, and most successful formal experiment in workers' control ever conducted in the United States."
Mutation in a cancer-causing gene could exacerbate cerebral cavernous malformations in the brain
Researchers have discovered an explanation for why cerebral cavernous malformations (CCMs) clusters of dilated blood vessels in the brain can suddenly grow to cause seizures or stroke. Specifically, they found that a specific, acquired mutation in a cancer-causing gene (PIK3CA) could exacerbate existing CCMs in the brain. Furthermore, repurposing an already existing anticancer drug showed promise in mouse models of CCMs in improving brain-vascular health and preventing bleeding into the brain tissue.
Previous studies linked the initial formation of CCMs to various environmental factors, including differences in the gut microbiome, and inactivating mutations in three specific genes collectively known as the CCM complex. While these changes are enough to cause small malformations to form in the brain, they didn t explain why some suddenly expand in size, resulting in seizures or stroke.
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Researchers have discovered an explanation for why cerebral cavernous malformations (CCMs) clusters of dilated blood vessels in the brain can suddenly grow to cause seizures or stroke. Specifically, they found that a specific, acquired mutation in a cancer-causing gene (PIK3CA) could exacerbate existing CCMs in the brain. Furthermore, repurposing an already existing anticancer drug showed promise in mouse models of CCMs in improving brain-vascular health and preventing bleeding into the brain tissue.
Previous studies linked the initial formation of CCMs to various environmental factors, including differences in the gut microbiome, and inactivating mutations in three specific genes collectively known as the CCM complex. While these changes are enough to cause small malformations to form in the brain, they didn t explain why some suddenly expand in size, resulting in seizures or stroke.
Cancer-linked mutation accelerates growth of abnormal stroke-causing brain blood vessels miragenews.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from miragenews.com Daily Mail and Mail on Sunday newspapers.