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Share Most vaccines require refrigeration to keep from going bad. The messenger RNA vaccines for COVID-19 require freezing temperatures. RONNY HARTMANN/AFP via Getty Images Here’s how scientists are designing vaccines that can ditch the fridge Apr. 21, 2021 , 3:30 PM From the cutting-edge vaccines for COVID-19 to the decades-old ones for poliovirus, most vaccines need to be kept cold to survive the trip from factory to patient. But that poses a major hurdle to even routine immunizations in countries like Mali or Bangladesh, where up to 90% of health facilities lack adequate refrigeration. To solve this problem, some researchers are working toward a radical goal: vaccine formulations that don’t have to be kept cold. Significant hurdles remain, but many scientists are optimistic that 10 years from now vaccination campaigns won’t be quite so hampered by the heat.

United statesCity ofUnited kingdomUniversity of texasMaria bottazziJames dinneenAsel sartbaevaBenjamin pierceCaryn heldtAmit khandharJason hallettMaria croyleHub at imperial college londonUniversity of washingtonTexas children hospital centerUniversity of bath