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Penn analysis shows low risk of secondary cancers following CAR T cell therapy

The development of any type of second cancer following CAR T cell therapy is a rare occurrence, as found in an analysis of more than 400 patients treated at Penn Medicine, researchers from the Perelman School of Medicine at the University of Pennsylvania reported today in Nature Medicine.

David porterJodi fisher horowitzMarco ruellaLymphoma programAbramson cancer centerUniversity of pennsylvaniaUniversity of pennsylvania school medicinePerelman school of medicinePennsylvania schoolPenn medicinePerelman schoolScientific directorPenn medicine cellular therapyTransplant biobankLeukemia care excellenceCell therapy

Secondary cancers following CAR T cell therap

PHILADELPHIA – The development of any type of second cancer following CAR T cell therapy is a rare occurrence, as found in an analysis of more than 400 patients treated at Penn Medicine, researchers from the Perelman School of Medicine at the University of Pennsylvania reported today in <a href="https://www.nature.com/articles/s41591-024-02826-w">Nature Medicine</a>. The team also described a single case of an incidental T cell lymphoma that did not express the CAR gene and was found in the lymph node of a patient who developed a secondary lung tumor following CAR T cell therapy.

United statesUniversity of pennsylvaniaChester countyPennsylvania hospitalNew jerseyJodi fisher horowitzMarco ruellaDavid porterPenn medicine princeton healthUniversity of pennsylvania health systemLancaster behavioral health hospitalLymphoma programAbramson cancer centerPerelman school of medicineNational institutes of healthPrinceton house behavioral health

Secondary cancers following CAR T cell therapy are rare, analysis shows

Secondary cancers following CAR T cell therapy are rare, analysis shows
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United statesGuido ghilardiMarco ruellaLymphoma programPerelman school of medicineUniversity of pennsylvaniaPerelman schoolScientific directorT cell lymphomaNature medicine

Secondary cancers following CAR T cell therap

Secondary cancers following CAR T cell therap
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New jerseyUnited statesUniversity of pennsylvaniaPennsylvania hospitalChester countyDavid porterJodi fisher horowitzMarco ruellaHospital of the university pennsylvaniaNational institutes of healthPrinceton house behavioral healthRuth perelman school of medicineLymphoma programAbramson cancer centerPerelman school of medicinePenn presbyterian medical center

Secondary Cancers Following CAR T Cell Therapy Are Rare

Secondary Cancers Following CAR T Cell Therapy Are Rare
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United statesUniversity of pennsylvaniaJodi fisher horowitzMarco ruellaDavid porterLymphoma programAbramson cancer centerPerelman school of medicinePenn medicinePerelman schoolUnited states manyScientific directorPenn medicine cellular therapyTransplant biobankLeukemia care excellenceCell therapy