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FAU researchers urge to prescribe aspirin based on benefit-to-risk not age

Recent guidelines have restricted aspirin use in the primary prevention of cardiovascular disease to patients under 70, and more recent guidance to patients under 60. Yet, the risks of heart attacks and strokes increase markedly with age.

United statesUnited kingdomBianca biglioneJ michael gazianoVictorj dzauLisac martinezSarahk woodDavidl demetsCharlesh hennekensEmily hendersonThomasd cookMarca pfefferJean bell mccabeAlexander gitinKyungmann kimSchmidt college of medicine

Sacubitril-Valsartan Does Not Cut Risk for Death, Heart Failure After MI

Sacubitril-Valsartan Does Not Cut Risk for Death, Heart Failure After MI
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United statesMarca pfefferHealthday newsNew england journal

Sacubitril-Valsartan Does Not Decrease Risk for Death, Heart Failure After MI

Sacubitril-valsartan is not associated with a reduced incidence of death from CV causes or incident heart failure compared with ramipril.

United statesMarca pfefferHealthday newsNew england journal

Effects of Dapagliflozin in Stage 4 Chronic Kidney Disease

Effects of Dapagliflozin in Stage 4 Chronic Kidney Disease
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PARADISE-MI: ARNI Doesn t Surpass ACE Inhibitor After Acute MI

May 15, 2021 For immediate post-MI patients, sacubitril/valsartan (Entresto; Novartis) does not significantly decrease the risk of heart failure (HF) or CV death compared with an ACE inhibitor, the PARADISE-MI trial shows. sacubitril/valsartan is superior to an ACE inhibitor in patients who have symptomatic HF with reduced ejection fraction when it comes to reducing both HF events and total mortality, PARADISE-MI fell short by missing its primary endpoint of a 15% reduction in events needed to demonstrate superiority of the angiotensin receptor neprilysin inhibitor (ARNI) over an ACE inhibitor, ramipril, in this acute MI population. Nevertheless, there was a 10% reduction in the sacubitril/valsartan group and positive reports of reduced events from investigators who participated in the large multinational trial.

United statesMary norine walshMarc pfefferLynne warner stevensonMarca pfefferAmerican college of cardiologyMd vanderbilt university medical centerPhd harvard medical schoolVincent heart centerHarvard medical schoolAmerican collegeVanderbilt university medical centerNorine walshஒன்றுபட்டது மாநிலங்களில்மேரி நோரின் வால்ஷ்மார்க் பிபெப்பேற்

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