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Kotoko coach Mariano Barreto made two changes to the side that started against Great Olympics in the previous games.
Brazilian attacker Fabio Gama Dos Santos returned to the XI after serving a suspension while Augustine Okrah was similarly restored to the team after recovering from an injury.
Medeama, on the other hand, had to do without Ghana midfielder Justice Blay, who sustained an injury while playing against Legon Cities on the previous matchday.
Unlike Blay who missed a chance to face former side Asante Kotoko, Burkina Faso striker Amed Toure had the opportunity but could only do so from the bench.