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DVIDS - News - First-Ever Malaria Vaccine Has Roots in Army Medical Research

DVIDS - News - First-Ever Malaria Vaccine Has Roots in Army Medical Research
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Monoclonal antibodies can be an effective tool in the global fight against malaria

Monoclonal antibodies can be an effective tool in the global fight against malaria Scientists at Walter Reed Army Institute of Research, in collaboration the Duke University, have confirmed that monoclonal antibodies can be an effective tool in the global fight against malaria. The study, led by Dr. Sheetij Dutta, chief of the Structural Vaccinology Laboratory at WRAIR, showed that mAbs such as CIS43 was most effective in a culture-based assay that measured a malaria parasite s ability to infect a human liver cell, while another mAb 317 showed the best activity in a mouse infection model. Dutta added, difference in assay outcomes for mAbs could reflect distinct sites on the circumsporozoite protein, that can be exploited for developing improved vaccines. The study results were published today in

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