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Massive Machine-Type Communications (mMTC) features a massive number of low-cost user equipment (UE) with sparse activity. Tailor-made for these features, grant-free random access (GF-RA) serves as an efficient access solution for mMTC. However, most existing GF-RA schemes rely on strict synchronization, which incurs excessive coordination burden for the low-cost UEs. In this work, we propose a receiver design for asynchronous GF-RA, and address the joint user activity detection (UAD) and channel estimation (CE) problem in the presence of asynchronization-induced inter-symbol interference. Specifically, the delay profile is exploited at the receiver to distinguish different UEs. However, a sample correlation problem in this receiver design impedes the factorization of the joint likelihood function, which complicates the UAD and CE problem. To address this correlation problem, we design a partially uni-directional (PUD) factor graph representation for the joint likelihood function. Buil

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