Of Breast Cancer. And a pair of best friends with a wish list thats inspiring america. This is nbc nightly news with lester holt. Good evening. And thank you for joining us. Its gone from bad to worse in Southern California as a fifth major wildfire breaks out, this one in los angeles itself. The fire broke out early this morning near brentwood and, fanned by strong winds, it quickly marched up hillsides along the infamous 405. Predawn commuters forced to drive a virtual flaming gauntlet through the busy sepulveda pass. Several homes have been destroyed. Tonight that fire threatens still more homes in some of l. A. s toniest neighborhoods. Many remain displaced by fires as a red flag warning for windy and dry conditions is expected to be up through tomorrow. Our National Correspondent miguel amagger is on the fire lines. Miguel, good evening. Reporter lester, good evening. This is the front lines. Th behind me scrambled out of their house in the middle of the night. This is what theyll