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Clarity s theranostic prostate cancer trial advances to highest dose level

Clarity s theranostic prostate cancer trial advances to cohort 2

Clarity s theranostic prostate cancer trial advances to cohort 2

Highlights Cohort 1 of the SECuRE trial has been completed in 6 participants with metastatic castrate-resistant prostate cancer (mCRPC) who received therapy with 67Cu SAR-bisPSMA at the lowest dose level of 4GBq. No dose limiting toxicities (DLTs) have been reported in cohort 1. The Safety Review Committee (SRC) has recommended that the trial continues to cohort 2. Recruitment has opened at clinical sites in the United States (US) at the cohort 2 dose level of 8GBq and patients are currently in screening for all available slots. Additional therapy cycles of 67Cu SAR-bisPSMA have been requested by clinicians under the US Food and Drug Administration (FDA) Expanded Access Program (EAP). Early data from the EAP indicates positive effects of the lowest dose of 67Cu SAR-bisPSMA on lesions, demonstrated by SPECT-CT images, with reduction in Prostate Specific Antigen (PSA) levels. SYDNEY, May 24, 2023 /PRNewswire/ Clarity Pharmaceuticals(ASX: CU6) ("Clarity", "the Company&quo

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