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Computer scientists aim to reveal the evolutionary trees of cancer mutations

Computer scientists aim to reveal the evolutionary trees of cancer mutations Rice University computer scientists will take full advantage of new technology to sequence the genome of a single cell and decode mysteries contained in tumors. Luay Nakhleh, recently named the William and Stephanie Sick Dean of Rice s Brown School of Engineering, has been awarded a four-year, $1.2 million National Science Foundation grant to analyze the genomes in colonies of single cancer cells to find not only the mutations at the root of the disease but also how they evolve from cell to cell as the tumor grows. Nakhleh, also a professor of computer science and of biosciences, and his team will use single-cell DNA data provided by colleagues at the University of Texas MD Anderson Cancer Center. They expect to reveal evolutionary trees of cancer mutations that could eventually help refine treatment for patients.

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