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January 21, 2021 The protein transthyretin (TTR) may play a role in the development of new treatments for Alzheimer’s disease by preventing the formation of amyloid beta clumps, according to a study published in the Journal of Biological Chemistry. Found in amyloid beta clumps, TTR has previously demonstrated an apparent protective effect against the development of Alzheimer’s disease. Mouse studies have shown that animals with more TTR are slower to develop Alzheimer’s-like symptoms, while those with less TTR develop the condition more quickly, researchers explained CREDIT: UT Southwestern Medical Center The new research discovery involves what researchers consider opposing functions of TTR. In healthy individuals, TTR forms a tetramer, a clover-resembling shape with 4 identical leaflets, to help transport thyroid hormone and the vitamin A derivative retinol throughout the body. But when the protein separates into molecules called monomers, TTR can form sticky fibrils

United statesLorena saelicesJolynn tumoloUt southwestern medical centerMedical centerஒன்றுபட்டது மாநிலங்களில்உட் தென்மேற்கு மருத்துவ மையம்மருத்துவ மையம்