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Individual neurons mix multiple RNA edits of key synapse protein, fly study finds

Individual neurons mix multiple RNA edits of key synapse protein, fly study finds
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Elizabeth brijaTroy littletonElizabetha brijaPicower institute forPicower instituteCognitive sciencesLittleton labCell reportsMenicon professorComplexinc terminus

Study connects neural gene expression differences to functional distinctions

Study connects neural gene expression differences to functional distinctions
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Troy littletonSuresh jettiSureshk jettiLittleton labCognitive sciencesPicower institute forPicower instituteMenicon professor

Key Protein Vital for Structural Integrity of Neurons – Without It Axons Break, Synapses Die

Key Protein Vital for Structural Integrity of Neurons – Without It Axons Break, Synapses Die
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Ellenj gussKarenl cunninghamKaren cunninghamJ troy littletonTroy littletonYulia akbergenovaCognitive sciencesNational institutes of healthLittleton labPicower institute forCourtesy of the littleton lab picower instituteNeuronal brain cell damage concept illustrationPicower instituteMenicon professorWithin broken neural axonGuss phd

Without a key extracellular protein, neuronal axons break and synaptic connections fall apart

MIT researchers found that without the protein perlecan, axonal segments in fruit flies can break apart during development. The synapses that they form end up dying away.

Yulia akbergenovaTroy littletonKaren cunninghamNational institutes of healthPicower institute forCognitive sciencesLittleton labPicower instituteMenicon professorGuss phdNational institutes

Neuronal Axons Break and Synaptic Connections Fall Apart Without Key Protein

Neuronal Axons Break and Synaptic Connections Fall Apart Without Key Protein
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Yulia akbergenovaKaren cunninghamTroy littletonLittleton labPicower institute forNational institutes of healthCognitive sciencesPicower instituteMenicon professorGuss phdNational institutes