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CureVac and the University Medical Center Mainz Start Phase 3 Clinical Trial for COVID-19 Vaccine Candidate, CVnCoV, in Healthcare Workers

The randomized, observer blind, placebo-controlled clinical Phase 3 study will include more than 2,500 subjects, 18 years of age and older, who will be randomized into this study out of the non-interventional trial. It complements the recent initiation of CureVacs global pivotal Phase 2b/3 trial, HERALD, for CVnCoV in more than 35,000 participants. The Phase 3 study builds on a non-interventional study on COVID-19 at the University Hospital Mainz involving 3,600 hospital employees, including medicine and dentistry students in their 5 th semester or higher. The study has been ongoing for several months and investigates the distribution (epidemiology) of COVID-19 in a collective of employees of a University Hospital. It focuses on the rate at which SARS-CoV-2-specific antibodies arise and can be detected in hospital employees as well as the frequency of virologically confirmed COVID-19 cases in this cohort of hospital employees.

CureVac Launches Specialized Phase 3 Clinical Trial of Coronavirus Vaccine Candidate

Moderna (NASDAQ:MRNA) has now moved into late-stage testing on healthcare workers. CureVac (NASDAQ:CVAC), like BioNTech a clinical-stage biotech based in Europe, announced Monday that its CvnCoV is about to enter phase 3 clinical trials, in testing that involves healthcare workers. The first participant in the study is to be administered the initial shot of the vaccine candidate on Tuesday. Image source: Getty Images. This crucial phase of testing will take place at the University Medical Center Mainz in Germany. It s a randomized, placebo-controlled study with over 2,500 individuals aged 18 and older. CureVac said it compliments the company s phase 2b/3 trial, which involved more than 35,000 people and began last week.

Investegate |CureVac Announcements | CureVac: CureVac and the University Medical Center Mainz Start Phase 3 Clinical Trial for COVID-19 Vaccine Candidate, CVnCoV, in Healthcare Workers

- Study builds on observational epidemiological study TÜBINGEN, Germany/ BOSTON, USA - December 21, 2020 - CureVac N.V. (Nasdaq: CVAC), a global clinical-stage biopharmaceutical company developing a new class of transformative medicines based on messenger ribonucleic acid (mRNA), announced today that the first participant in a clinical Phase 3 study with its COVID-19 vaccine, CVnCoV, in healthcare workers at the University Medical Center Mainz will be vaccinated on December 22, 2020. The study aims to evaluate the safety and immunogenicity of CVnCoV administered as a two-dose schedule of 12 µg. The trial follows an epidemiological, non-interventional study conducted with healthcare workers from the University Hospital in Mainz.

CureVac set to begin phase 3 COVID-19 vaccine study in healthcare workers

CureVac set to begin phase 3 COVID-19 vaccine study in healthcare workers First participant will be vaccinated on 22 December CureVac is set to launch a new phase 3 study of its COVID-19 vaccine in healthcare workers at the University Medical Center Mainz in Germany. The Tübingen, Germany-headquartered company expects to vaccinate the first participant in this phase 3 study on 22 December 2020. The study will evaluate the safety and efficacy of CureVac’s investigational CVnCoV vaccine, which will be administered as a two-dose regimen. The planned phase 3 study in healthcare workers builds on CureVac’s ongoing non-interventional study, which is investigating the distribution of COVID-19 in employees at University Medical Center Mainz.

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