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Multicellular organisms, like animals and plants, have complex cells with diverse functions. This complexity arises from the need for cells to produce distinct proteins that interact with each other. This interaction is crucial for cells to carry out their specific tasks and to form complex molecular machinery. However, our current understanding of such protein-protein interactions often lacks cellular contexts because they were usually studied in an in vitro system or in cells isolated from their tissue environment. Effective methods to investigate protein-protein interactions in a tissue-specific manner are largely missing.

Xiang david liLi ka shingXiang davidChaogu zhengSchool of biomedical sciencesProceedings of the national academy sciencesDepartment of chemistrySchool of biological sciencesUniversity of hong kongHong kongProfessor xiang davidProfessor chaoguBiological sciencesBiomedical sciencesMethionine analog based cell specific proteomicsNational academy