Micorscope is used by researcher who use her hands holding and adjusting while science research in laboratory
Researchers at University of Alberta have uncovered a link between the expression of the protein galectin-9 (gal-9) and whether a cancer patient will benefit from immunotherapy.
The discovery could help inform physicians about which patients will likely respond to immunotherapy, and lead to better treatment options.
Shokrollah Elahi, a member of the Cancer Research Institute of Northern Alberta (CRINA), collaborated with oncology professor John Walker on Phase 2 clinical trial that examined 40 patients with virus-associated solid tumours (VASTs) who were put on immunotherapy.
They found there was a direct link between patients with high levels of gal-9 and those who had a poor prognosis and did not respond to immunotherapy. Further, patients with lower levels of gal-9 responded better to treatment.
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University of Alberta lab reveals how a much-needed oral antiviral drug confuses replication machinery of SARS-CoV-2
A University of Alberta virology lab has uncovered how an oral antiviral drug works to attack the SARS-CoV-2 virus, in findings published May 10 in the Journal of Biological Chemistry.
The researchers demonstrated the underlying mechanism of action by which the antiviral drug molnupiravir changes the viral genome, a process known as excessive mutagenesis or “error catastrophe.”
“The polymerase, or replication engine of the virus, mistakes molnupiravir molecules for the natural building blocks required for viral genome replication and mixes them in,” explained Matthias Götte, professor and chair of the Department of Medical Microbiology & Immunology in the Faculty of Medicine & Dentistry and member of the Li Ka Shing Institute of Virology. “It causes the polymerase to make sloppy copies nonsense genomes that are useless and not viable.
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IMAGE: Mutagenesis Model of Molnupiravir. SARS-CoV-2 polymerase (oval) mediated nucleotide incorporation into the RNA primer (grey circles)/template (white circles). Plus and minus sense indicate RNA sense. A, C, G, and U. view more
Credit: Supplied by Matthias Gotte
A University of Alberta virology lab has uncovered how an oral antiviral drug works to attack the SARS-CoV-2 virus, in findings published May 10 in the
Journal of Biological Chemistry.
The researchers demonstrated the underlying mechanism of action by which the antiviral drug molnupiravir changes the viral genome, a process known as excessive mutagenesis or error catastrophe. The polymerase, or replication engine of the virus, mistakes molnupiravir molecules for the natural building blocks required for viral genome replication and mixes them in, explained Matthias Götte, professor and chair of the Department of Medical Microbiology & Immunology in the Faculty of Medicine & Dentistry and
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Sure as a narrow band of clear sky on the western horizon, with storm clouds hanging overhead, there is a bright future ahead for the province.
Doug Schweitzer, Minister of Jobs, Economy and Innovation, addressed an audience from the Grande Prairie and District Chamber of Commerce about the provinceâs outlook.
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Try refreshing your browser. Economic optimism provides hope in the provinceâs future Back to video
âI think the biggest thing we are seeing right now and that we see for the second half of 2021 is going to be a rebound in some of our biggest economic drivers for the province of Alberta, namely being oil and gas,â said Schweitzer during an interview after the address. âWe are seeing a significant uptake in WTI (West Texas Intermediate oil) pricing, in particular. Right now, it is hovering in the mid-$US60 range. There are some forecasts having oil going up to the $US70 US to $US80
Article content
Sure as a narrow band of clear sky on the western horizon, with storm clouds hanging overhead, there is a bright future ahead for the province.
Doug Schweitzer, Minister of Jobs, Economy and Innovation, addressed an audience from the Grande Prairie and District Chamber of Commerce about the provinceâs outlook.
We apologize, but this video has failed to load.
Try refreshing your browser. Economic optimism provides hope in the provinceâs future Back to video
âI think the biggest thing we are seeing right now and that we see for the second half of 2021 is going to be a rebound in some of our biggest economic drivers for the province of Alberta, namely being oil and gas,â said Schweitzer during an interview after the address. âWe are seeing a significant uptake in WTI (West Texas Intermediate oil) pricing, in particular. Right now, it is hovering in the mid-$US60 range. There are some forecasts having oil going up to the $US70 US to $US80