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Genotype-First Approach Offers Disease Insights

U.S researchers have shown that using common genetic variants as the starting point for investigating a disease can provide greater insights than beginning with its physical manifestation in the body.

United statesJulia fekecsLeslie bieseckerCaralynn wilczewskiUs national institutes of healthNational human genome research institutePrecision health researchNational human genome researchAmerican journalReverse phenotyping

New approach puts genotype first

Researchers have assessed 13 studies that took a genotype-first approach to patient care, in contrast to the more typical phenotype-first approach.

United statesElissa wolfsonLeslie bieseckerNational institute of allergyPrecision health researchScience advisory boardAmerican journalHuman geneticsNational human genome research instituteReverse phenotyping corePrecision healthNational instituteInfectious diseaseCentralized sequencing protocolReverse phenotyping core genomic dataGenomic medicine

Genetic Disorders Traced to Genomic Variants with New Method

Genetic Disorders Traced to Genomic Variants with New Method
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United statesLeslie bieseckerClesson turnerCaralynn wilczewskiNational institute of allergyNational institutes of healthNational human genome research institutePrecision health researchNational institutesAmerican journalReverse phenotyping corePhenotyping corePrecision healthNational instituteInfectious diseaseCentralized sequencing protocol

Genotype-first approach uncovers new relationships between genes and clinical conditions

National Institutes of Health researchers have published an assessment of 13 studies that took a genotype-first approach to patient care.

United statesLeslie bieseckerClesson turnerCaralynn wilczewskiEmily hendersonNational institute of allergyNational institutes of healthNational human genome research institutePrecision health researchAmerican journalReverse phenotyping coreGenomics industry focusPhenotyping corePrecision healthNational instituteInfectious disease

Controversy flares over informing research subjects about incidental genetic findings | Science

Controversy flares over informing research subjects about incidental genetic findings | Science
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United statesBaylor college of medicineUniversity of texasDake kangSusan wolfRobert nussbaumLeslie bieseckerBen berkmanMeredith wadmanKeisha rayNational institutes of healthUniversity of texas health science centerMcgovern centerDepartment of bioethicsHarvard universityNational human genome research institute