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Clinical trials of tuberculosis vaccines in the era of increased access to preventive antibiotic treatment

Approximately 10·6 million people worldwide develop tuberculosis each year, representing a failure in epidemic control that is accentuated by the absence of effective vaccines to prevent infection or disease in adolescents and adults. Without effective vaccines, tuberculosis prevention has relied on testing for Mycobacterium tuberculosis infection and treating with antibiotics to prevent progression to tuberculosis disease, known as tuberculosis preventive treatment (TPT). Novel tuberculosis vaccines are in development and phase 3 efficacy trials are imminent.

Community Care in the AIDS Crisis

Today, entire neighborhoods are caring for each other. In the wake of the COVID-19 pandemic, mutual aid has proven an effective response, even if it is not ideal. While these efforts are often contextualized within a radical heritage that includes the Black Panther Party’s community programs of the 1960s and 1970s, these genealogies of mutual aid tend to overlook queer care and volunteer responses to AIDS in the 1980s. Looking deeper at that response can shed light on commonalities between the AIDS/HIV and COVID-19 crises, but it also points to a much deeper tradition of the capacity of humans to care for one another, independent of the state (especially when its response has been negligent).

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