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Cells monitor for ribosome collisions to determine the severity of the problem and how best to respond when things start to go awry, research in yeast shows.
Ribosomes are the machines in the cell that use instructions from mRNA to synthesize functional proteins. There are hundreds of thousands of ribosomes in each cell, and they mostly process their instructions faithfully. But sometimes ribosomes get stuck or stall on roadblocks along defective mRNA molecules.
“The cell has two methods of stress response that are triggered by this very same signal of ribosomes running into each other,” says Hani Zaher, associate professor of biology at Washington University in St. Louis. “However, the quality control mechanism of ribosome rescue and mRNA degradation responds more swiftly to resolve the problems and to prevent premature activation of the integrated stress response.
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Ribosomes are the machines in the cell that use instructions from mRNA to synthesize functional proteins. There are hundreds of thousands of ribosomes in each cell, and they mostly process their instructions faithfully. But sometimes ribosomes get stuck or stall on roadblocks along defective mRNA molecules.
New research from Washington University in St. Louis shows that cells monitor for ribosome collisions to determine the severity of the problem and how best to respond when things start to go awry.
The research from the laboratory of Hani Zaher, associate professor of biology in Arts & Sciences, is published online Dec. 17 in the journal Molecular Cell.
(Image: Shutterstock)
Ribosomes are the machines in the cell that use instructions from mRNA to synthesize functional proteins. There are hundreds of thousands of ribosomes in each cell, and they mostly process their instructions faithfully. But sometimes ribosomes get stuck or stall on roadblocks along defective mRNA molecules.
Zaher
New research from Washington University in St. Louis shows that cells monitor for ribosome collisions to determine the severity of the problem and how best to respond when things start to go awry.
The research from the laboratory of Hani Zaher, associate professor of biology in Arts & Sciences, was published in the journal Molecular Cell.
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