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Treating donor stem cells from horses with a growth factor called TGF-β2 may allow the cells to avoid “tripping” the immune response in recipients, according to new research.
The work could simplify the stem cell treatment process for ligament and tendon injuries in horses, and may also have implications for human stem cell therapies.
Mesenchymal stem cell therapy is a promising avenue for treating musculoskeletal injuries particularly tendon and ligament injuries in horses. Mesenchymal stem cells are adult stem cells found in bone marrow that act as repair directors, producing secretions that recruit paracrine, or healing, factors to the site of injury.
Horsetalk.co.nz Researchers curb local immune response in horses receiving stem cell injury therapy
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Cultures with treated stem cells had a 50% higher stem cell survival rate than untreated cultures. Image by carolem41
Treating equine donor stem cells with a growth factor called TGF-β2 may allow them to avoid “tripping” the immune response in recipients, according to new research.
The work carried out at North Carolina State University could simplify the stem cell treatment process for ligament and tendon injuries in horses, and may also have implications for human stem cell therapies.
Mesenchymal stem cell therapy is a promising avenue for treating musculoskeletal injuries, particularly tendon and ligament injuries, in horses.