comparemela.com

Latest Breaking News On - Laura image - Page 1 : comparemela.com

Combination of tucatinib and neural stem cells secreting anti-HER2 antibody prolongs survival of mice with metastatic brain cancer

Brain metastases are among the most severe complications of systemic breast cancer, and overexpression of the human epidermal growth factor receptor 2 (HER2) in breast cancer cells increases the incidence of brain metastases in patients. In this study, we engineered the human-derived, tumor cell tropic neural stem cells LM-NSC008 (LM008) to continuously secrete antibodies against HER2. These anti-HER2 antibodies impaired tumor cell proliferation by inhibiting the PI3K-Akt signaling pathway in HER2+ breast cancer cells in vitro. Importantly, our results demonstrate that the therapeutic combinatorial regimen consisting of LM-NSC008 anti-HER2 antibody-secreting cells and the HER2 kinase inhibitor tucatinib provide therapeutic benefit and prolong survival in preclinical models of HER2+ breast cancer brain metastases.

Dudu Braga morre: filho de Roberto Carlos ficou cego aos 23 anos

Dudu Braga morre: filho de Roberto Carlos ficou cego aos 23 anos
uol.com.br - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from uol.com.br Daily Mail and Mail on Sunday newspapers.

Free Fire: as mudanças em Paloma, Evelyn e Laura valem a pena?

Free Fire: as mudanças em Paloma, Evelyn e Laura valem a pena?
uol.com.br - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from uol.com.br Daily Mail and Mail on Sunday newspapers.

Laura Müller: Erstes Posting seit Weihnachten und sie sieht verändert aus

Laura Müller: Erstes Posting seit Weihnachten und sie sieht verändert aus
msn.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from msn.com Daily Mail and Mail on Sunday newspapers.

© 2024 Vimarsana

vimarsana © 2020. All Rights Reserved.