It s important to challenge and debunk misinformation in a positive, constructive manner. - Stephan Lewandowsky Developed by a team of scientists and volunteers from many academic disciplines, this handbook is designed to arm people with practical tips, information, and evidence grounded in behavioural science to talk about COVID-19 vaccines, constructively challenge associated myths, and allay fears. The handbook, which could be of use to journalists, doctors, nurses, policymakers, researchers, teachers, students, parents, and others, is self-contained but also provides access to a living wiki of more detailed information. The project is a creation of SciBeh, a group working to reconfigure behavioural science for crisis knowledge management.