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Review Highlights Potential of Neoadjuvant Immune Checkpoint Inhibition in Multiple Cancers

Recent evidence suggests that neoadjuvant immunotherapy offers a unique opportunity to explore disease mechanisms and identify new biomarkers of immune checkpoint blockade response and resistance, according to the researchers.

Suzanne topalianBloomberg kimmel institute for cancer immunotherapyJohns hopkins kimmel cancer centerJohns hopkins melanoma skin cancer programCancer cellKimmel instituteJohns hopkinsSkin cancer programImmune checkpoint inhibitorsImmune checkpoint blockade

Neoadjuvant immunotherapy shows promise in multiple cancer types

Treating cancer with immunotherapies known as an immune checkpoint blockade (ICB) prior to surgery (so-called neoadjuvant immunotherapy) has been a rapidly growing area of research, but the scientific community is just scratching the surface of what is possible, according to a review article co-authored by several current and former investigators from the Bloomberg~Kimmel Institute for Cancer Immunotherapy and the Johns Hopkins Kimmel Cancer Center.

Lily ramseyJohns hopkinsSuzanne topalianKellie smithPatrick fordeMark yarchoanJohns hopkins kimmel cancer centerJohns hopkins melanoma skin cancer programBloomberg kimmel institute for cancer immunotherapyKimmel instituteJohns hopkins kimmel cancerSkin cancer programCancer cellDrew pardollLeisha emensBreast cancer

Immune checkpoint blockade prior to surgery promising in multiple cancer types, finds study

Immune checkpoint blockade prior to surgery promising in multiple cancer types, finds study
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Suzannel topalianSuzanne topalianJohns hopkins melanoma skin cancer programBloomberg kimmel institute for cancer immunotherapyJohns hopkins kimmel cancer centerKimmel instituteJohns hopkins kimmel cancerJohns hopkinsSkin cancer programCancer cell

More studies needed to understand true impact of microbiota on cancer development, treatment

More studies needed to understand true impact of microbiota on cancer development, treatment
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Jessica queenJohns hopkinsFyza shaikhCynthia searsJohns hopkins kimmel cancer centerBloomberg kimmel institute for cancer immunotherapyJohns hopkins bloomberg school of public healthJohns hopkins university school of medicineNature cancerKimmel instituteJohns hopkins university schoolKimmel professorshipJohns hopkins bloomberg school

New trial shows promise of combination neoadjuvant immunotherapy for lung cancer

Patients with stage 1–3 non-small cell lung cancer (NSCLC) given a combination immunotherapy prior to surgery (neoadjuvant) had a better major pathological response (10% or less residual cancer) when the cancer was removed than those who took a single immunotherapy agent alone, according to results of a novel multicenter phase 2 NeoCOAST platform trial that included two investigators from the Johns Hopkins Kimmel Cancer Center and its Bloomberg-Kimmel Institute for Cancer Immunotherapy.

United statesMegan craigPatrick fordeBloomberg kimmel institute for cancer immunotherapyAmerican association for cancer researchJohns hopkins kimmel cancer centerBloomberg kimmel instituteCancer discoveryAmerican associationKimmel instituteLung cancerAncer immunotherapyNon small cell lung cancerPd l1Small cell lung cancer