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The NPAS4 gene may play a critical role in linking long-term stress to depression and depressive behaviors. The findings may lead to new, targeted treatments for depression as a result of chronic stress.
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MEF2C, a gene critical for brain development and regulating circuit formation in the brain also plays a significant role in inner ear development. Mutations of MEF2C have previously been linked to ASD. Researchers found mice with only one copy of the MEF2C gene had reduced activity in the auditory nerve.