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Avrobio Keeps Its Platform Closed and Compact Source: poba/Getty Images Instead of jumping into building a big bioprocessing facility, leaders at Avrobio started small. This clinical-stage gene-therapy company, headquartered in Cambridge, MA, focused on automation and computation. “We wanted to produce consistent, high-quality products, but do it in a way that was easy to scale,” says Kim Raineri, Avrobio’s chief manufacturing and technology officer. He and his colleagues turned off-the-shelf instruments into a system that accommodates the methods controlled by the company’s proprietary algorithm to make lentiviral-based gene therapy. Raineri calls the resulting system “nearly fully closed and very nimble.” To switch the product being produced, “you just swap out the vector that provides the gene of interest,” Raineri adds.

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