Kyoto University The Noriyuki Tsumaki lab reports the effects of gene editing monkey iPS cells on regenerative medicine for damaged knee cartilage. Immune rejection is one of the biggest obstacles to a cell therapy. To solve this problem, researchers have been investigating iPS cells that have been gene edited so that they can evade the immune system. While this concept is theoretically possible, there is limited evidence that it works in species resembling humans. A new study by the laboratory of CiRA Professor Noriyuki Tsumaki shows that this strategy is more complicated than expected when using monkey iPS cells to treat damaged knee cartilage in monkeys. The study can be read in Tissue Engineering Part A.