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Apr 16, 2021
Dual users also had reduced tobacco toxicant exposures at 24 weeks
Smokers using high-nicotine electronic cigarettes to cut down on their cigarette consumption were more successful in doing so than smokers given low-nicotine or no-nicotine cigarettes substitutes, and they also had lower exposures to tobacco-related carcinogens in a clinical trial with more than 500 participants followed for six months.
Total urinary concentration of the tobacco toxicant 4-(methelnitrosamino)-1-(3-pyridy)-1-butanol (NNAL) was significantly reduced over 24-weeks in the smokers who used electronic nicotine delivery systems (ENDS) with nicotine delivery equivalent to combustible cigarettes.
Smoking declined by 58% in the group during the period, with daily cigarette use reduced from an average of close to 18 cigarettes per day at baseline to 7.43 at 24 weeks.