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Breast Cancer Drugs Can Be Repurposed for Cancers with Splice Mutation

Scientists at the Queen’s University of Belfast and the University of Birmingham have found a variety of cancers with mutations in the SF3B1 gene that forms part of the cellular splicing machinery respond to existing drugs that inhibit the enzyme poly ADP ribose polymerase (PARP). Currently PARP inhibitors used to treat cancers with mutations in the BRCA1 and BRCA2 genes. With PARP inhibitors already widely available, the study indicates it may be possible to treat patients with rare and difficult-to-treat cancers bearing mutations in SF3B1, using these repurposed drugs.

United kingdomKatrina lappinMichelle mitchellCancer researchQueen university of belfastUniversity of birminghamPatrickg johnson centre

QUB scientists discover breakthrough in treatment of genetic blood cancers

A DEFECTIVE gene normally found in blood cancers can be treated with existing drugs that will ultimately improve survival rates, Belfast scientists have discovered.

United kingdomUnited statesKatrina lappinMichelle mitchellCancer researchQueen university belfastAmerican association for cancer researchUnited kingdom medical research councilCancer research united kingdomUniversity of birminghamHospital children charityUniversity belfastKienan savagePatrickg johnson centreAmerican associationChief executive

Defective gene in blood cancers could be treated with already available drugs

A defective gene, normally found in blood cancers, could be treated with drugs already available for cancers with similar gene defects, scientists at Queen’s University Belfast and the University of Birmingham have revealed.

United kingdomUnited statesAimee molineuxKatrina lappinMichelle mitchellQueen university belfastUnited kingdom medical research councilUniversity of birminghamCancer researchAmerican association for cancer researchCancer research united kingdomResearch councilHospital children charityUniversity belfastImage creditMedical research council

Mutation Pattern Similarity broadens potential of existing Therapies

Scientists at Queen’s University Belfast and the University of Birmingham have revealed that tumours normally found in blood cancers with mutations in the SF3B1 gene, are capable of responding to some existing PARP inhibitors, a type of drug used to treat cancers which carry similar mutations in the BRCA1 and BRCA2 genes. Click to read more.

United statesUnited kingdomKatrina lappinCancer researchAmerican association for cancer researchUnited kingdom medical research councilScientists at queen university belfastCancer research united kingdomUniversity of birminghamHospital children charityUniversity belfastKienan savagePatrickg johnson centreProfessor grant stewartBlood cancer united kingdomGreat ormond street hospital children

Blood cancer case drop during pandemic a real concern say Leukaemia & Lymphoma NI

Blood cancer case drop during pandemic a real concern say Leukaemia & Lymphoma NI
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United kingdomNorthern irelandRichard buchananKatrina lappinPatrickg johnston centreCancer researchBelfast cityBelfast city hospital