Throughout the COVID-19 pandemic, the range of clinical outcomes for individuals infected with SARS-CoV-2 varied widely, from showing no symptoms to succumbing to the disease. A research team from the Institut Pasteur, the CNRS, and the Collège de France collaborated with international scientists to
During the COVID-19 pandemic, the clinical spectrum observed among people infected with SARS-CoV-2 ranged from asymptomatic carriage to death. Researchers at the Institut Pasteur, the CNRS and the Collège de France, in collaboration with researchers around the world , have investigated the extent and drivers of differences in immune responses to SARS-CoV-2 across populations from Central Africa, Western Europe and East Asia. They show that latent cytomegalovirus infection and human genetic factors, driven by natural selection, contribute to population differences in immune response to SARS-CoV-2 and the severity of COVID-19. Understanding the factors underlying such population disparities could help to improve patient management in future epidemics. These results were published on August 9, 2023 in Nature.
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Diverse patterns of COVID-19 epidemics have been observed in populations with varied social demographics, vaccination coverages, past waves of outbreaks, and public health and social measures (PHSMs) implemented in response. This seminar will discuss how nowcasting of the Omicron epidemics was enhanced from January to August 2022 in Hong Kong by integrating evolving data streams that gradually became available and implemented the model in the nowcasting of Beijing’s Omicron BF.7 epidemics in November 2022 to January 2023.
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