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Intra-host SARS-CoV-2 composition varies over time, hinting at viral evolution during infection

Glycosylation a significant element in SARS-CoV-2 infection and vaccine design, says study

A new study by researchers from Taiwan and the US suggests that the removal of unnecessary glycans from spike glycoprotein of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) exposes highly conserved sequences and opens the door for the development of broadly protective vaccines against the virus and its variants.

How do common mutations in SARS-CoV-2 s spike affect its binding affinity with host cell receptors?

How do common mutations in SARS-CoV-2 s spike affect its binding affinity with host cell receptors?
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Researchers design compounds that prevent SARS-CoV-2 entry in human lung cells

Researchers design compounds that prevent SARS-CoV-2 entry in human lung cells Researchers have designed a new class of TMPRSS2 inhibitors that have shown broad antiviral activity against coronaviruses, including the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Although several vaccines have now been approved for combating coronavirus disease 2019 (COVID-19), there are as yet no safe, targeted and effective drugs available for its treatment. Remdesivir and some other broad-spectrum antivirals have been repurposed (with emergency approval) to treat severe COVID-19, though has shown mixed success as a therapeutic avenue. One potential target for drug development is viral proteases, like the papain-like protease (PLpro) or the 3C-like protease (3CL or Mpro), as well as other host proteases involved in viral entry and replication.

What is Exon Skipping?

What is Exon Skipping? Hereditary conditions cause those who suffer from them to live shorter lives with traumatic health issues. Because of this, researchers in the field of genetics are constantly exploring and developing gene therapies to cure them or alleviate the worst of their effects. This article will explore one such therapy which has showed real promise for inherited conditions, the process of exon skipping. Image Credit: Juan Gaertner/Shutterstock.com What are exons? All life is governed by genetics. In organisms that reproduce sexually, the parents pass down information in the form of genes to their offspring. Most of the time these genes code for healthy functions, but occasionally there are mutations that can cause an offspring to develop potentially fatal flaws in their genetic code.

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