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After the p53 tumour suppressor gene, the genes most frequently found mutated in cancer are those encoding two proteins of the SWI/SNF chromatin remodelling complex. This complex s function is to accommodate the histones that cover the DNA of the chromosomes so that the processes of transcription, DNA repair and replication or chromosome segregation can occur, as appropriate. A group from the University of Seville has demonstrated at CABIMER that the inactivation of BRG1, the factor responsible for the enzymatic activity of the SWI/SNF complexes, leads to high genetic instability, a characteristic common to the vast majority of tumours.
âLet others do the inventing!â wrote the novelist and philosopher Miguel de Unamuno, about what he perceived as his fellow Spaniardsâ lack of scientific and innovative spirit in the early 20th century. But Unamunoâs criticism was somewhat wide of the mark as, in fact, much has been invented in Spain, and at times so brilliantly that the result has been adopted globally.
Many of these innovations can now be viewed in a curious virtual museum, the Museum of Comfort, launched by the French carmaker Citroën â its new model, the C4, was designed in Spain â and accessible on Instagram. The exhibition is divided into four sections: comfort, design, technology and electricity â and takes the viewer back several centuries, presenting objects that are now perfectly familiar to us such as the lollipop, the mop, the guitar, the stapler, the penknife, foosball, the submarine, the spacesuit and the fan, to mention a few. The museum is the brainchild of design
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Researchers from the University of Seville and the University of Pavia have identified a link between Amyotrophic Lateral Sclerosis (ALS) and the accumulation of DNA-RNA hybrids in the genome. The accumulation of these hybrids causes increased genomic damage and boosts genetic instability. This finding will make it possible to better understand the molecular basis of the disease, as well as to propose new solutions to curb it.
Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease of the central nervous system, characterised by progressive degeneration of motor neurons leading to muscle paralysis. Classified as a rare disease, there is no cure despite efforts to understand the disease s molecular basis and research devoted to identifying therapies that can at least slow its evolution.