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From left: Hongbo Chi, Ph.D., Hongling Huang, Ph.D., and PeiPei Zhou, Ph.D., all of St. Jude Immunology, have mapped the previously unknown biological.
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Discovery offers potential for stripping tumors of T cell protection
First author Seon Ah Lim, Ph.D., and corresponding author Hongbo Chi, Ph.D., both of St. Jude Immunology, contributed to research that raises the potential for treatments that render tumors more vulnerable to cancer immunotherapy.
Immunologists at St. Jude Children’s Research Hospital have discovered that tumors use a unique mechanism to switch on regulatory T cells to protect themselves from attack by the immune system. Surprisingly, the mechanism does not affect regulatory T cell function outside the tumor and may therefore limit the immune-associated toxicities of targeting regulatory T cells.