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Vaccine-like mRNA injection can be used to make CAR T cells in body

New approach with mRNA preparation reprograms T cells to attack heart fibroblasts

An experimental immunotherapy can temporarily reprogram patients' immune cells to attack a specific target via only a single injection of messenger RNA (mRNA), similar to the mRNA-based COVID-19 vaccines, according to a new study from researchers in the Perelman School of Medicine at the University of Pennsylvania.

CAR T Cells Generated In Vivo Reverse Fibrosis, Restore Cardiac Function in Mice with Heart Failure

Study results suggest that a novel immunotherapy approach could be developed as a personalized platform to treat various fibrotic diseases or associated disorders.

Penn Medicine Awarded Nearly $7 Million for First Year of Contract to Study Influenza Viruses

Date Time Penn Medicine Awarded Nearly $7 Million for First Year of Contract to Study Influenza Viruses PHILADELPHIA The National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, has selected Penn Medicine as one of five sites across the country to serve as a Center of Excellence for Influenza Research and Response (CEIRR), with the goal of better understanding influenza viruses around the world along with learning about the viral strains that have the potential to cause pandemics. Penn Medicine has been awarded nearly $7 million in first-year funding. The contract is expected to be supported for six additional years.

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