Page 15 - Jonathan Kipnis News Today : Breaking News, Live Updates & Top Stories | Vimarsana

Boosting the Brain s Garbage Disposal Could Assist Alzheimer s Therapies

The drainage network in a mouse s brain is outlined in blue and green, and dotted with clumps of the Alzheimer s protein amyloid beta (red). Researchers at Washington University School of Medicine in St. Louis have found that improving the function of the network, known as the meningeal lymphatics, can make certain experimental Alzheimer s therapies more effective in mice. Credit: Sandro Da Mesquita Read Time: Experimental Alzheimer s drugs have shown little success in slowing declines in memory and thinking, leaving scientists searching for explanations. But new research in mice has shown that some investigational Alzheimer s therapies are more effective when paired with a treatment geared toward improving drainage of fluid and debris from the brain, according to a study led by researchers at Washington University School of Medicine in St. Louis.

David holtzmanJonathan kipnisGretchenp jonesCarlos cruchagaOscar harariEdithl wolffPuretech healthDepartment of neurologyWashington university school of medicineExperimental alzheimerWashington university schoolDistinguished professorடேவிட் ஹோல்ட்ஸ்மேன்ஜொனாதன் கிப்னிச்துறை ஆஃப் நரம்பியல்வாஷிங்டன் பல்கலைக்கழகம் பள்ளி ஆஃப் மருந்து

Repairing faulty drains could be key to unlocking the potential of Alzheimer s therapies

Repairing faulty drains could be key to unlocking the potential of Alzheimer s therapies Experimental Alzheimer s drugs have shown little success in slowing declines in memory and thinking, leaving scientists searching for explanations. But new research in mice has shown that some investigational Alzheimer s therapies are more effective when paired with a treatment geared toward improving drainage of fluid -; and debris -; from the brain, according to a study led by researchers at Washington University School of Medicine in St. Louis. The findings, published April 28 in the journal Nature, suggest that the brain s drainage system -; known as the meningeal lymphatics -; plays a pivotal but underappreciated role in neurodegenerative disease, and that repairing faulty drains could be a key to unlocking the potential of certain Alzheimer s therapies.

David holtzmanJonathan kipnisGretchenp jonesCarlos cruchagaOscar harariEdithl wolffEmily hendersonPuretech healthDepartment of neurologyStudy coWashington university school of medicineWashington university schoolDistinguished professorStudy co authorடேவிட் ஹோல்ட்ஸ்மேன்ஜொனாதன் கிப்னிச்

PureTech talks breakthroughs in Alzheimer s disease treatment

PureTech talks breakthroughs in Alzheimer s disease treatment
outsourcing-pharma.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from outsourcing-pharma.com Daily Mail and Mail on Sunday newspapers.

Jonathan kipnisJoe bolenWashington university school of medicineWashington university schoolஜொனாதன் கிப்னிச்ஓஹோ போலென்வாஷிங்டன் பல்கலைக்கழகம் பள்ளி ஆஃப் மருந்துவாஷிங்டன் பல்கலைக்கழகம் பள்ளி

Could unclogging the brain s drainage system improve the efficacy of Biogen s aducanumab in Alzheimer s?

Apr 28, 2021 11:00am A new Nature study has found that improving the function of the brain s drainage system, known as meningeal lymphatics (blue and green), could potentially make Biogen s Alzheimer s candidate aducanumab more effective in mice. (Sandro Da Mesquita) One popular theory in the quest to develop cures for Alzheimer’s disease is that targeting the toxic clumps of the protein beta-amyloid in the brain that are a hallmark of the disease could ameliorate symptoms. One such anti-amyloid drug, Biogen and Eisai’s aducanumab, has shown mixed efficacy in slowing cognitive decline in two clinical trials, while several similar candidates have simply failed to register any benefit, leaving many doubtful about the strategy.

Jonathan kipnisPuretech healthWashington university school of medicineWashington university schoolTech healthஜொனாதன் கிப்னிச்வாஷிங்டன் பல்கலைக்கழகம் பள்ளி ஆஃப் மருந்துவாஷிங்டன் பல்கலைக்கழகம் பள்ளிதொழில்நுட்பம் ஆரோக்கியம்

Brain s waste removal system may offer path to better outcomes in Alzheimer s therapy | National Institutes of Health (NIH)

NIH-funded study in mice suggests lymphatic boost could help reduce amyloid buildup. Study of mouse brain shows the meningeal lymphatics system (purple and pink) could help reduce amyloid. Sandro Da Mesquita, Ph.D. Enhancing the brainâs lymphatic system when administering immunotherapies may lead to better clinical outcomes for Alzheimerâs disease patients, according to a new study in mice. Results published April 28 in Nature suggest that treatments such as the immunotherapies BAN2401 or aducanumab might be more effective when the brainâs lymphatic system can better drain the amyloid-beta protein that accumulates in the brains of those living with Alzheimerâs. Major funding for the research was provided by the National Institute on Aging (NIA), part of the National Institutes of Health, and all study data is now freely available to the broader scientific community.

Jonathan kipnisRichardj hodesMollyv wagsterBehavioral systems neuroscience branchUs department of healthHuman servicesNational institutes of healthDiscovery into healthWashington university school of medicineDivision of neuroscienceResearch implementation milestoneNational institute on agingNational instituteNational institutesSystems neuroscience branchWashington university school