RICHMOND, Va. — New research from scientists at VCU Massey Comprehensive Cancer Center and the VCU Institute of Molecular Medicine (VIMM) determined that a particular gene — MDA-9/Syntenin-1/SDCBP — is
RICHMOND, Va. — New research from scientists at VCU Massey Comprehensive Cancer Center and the VCU Institute of Molecular Medicine (VIMM) determined that a particular gene — MDA-9/Syntenin-1/SDCBP — is
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IMAGE: Control mice (left panel) with prostate cancer show large areas of metastasis in the lungs (blue). When a subset of animals were treated with unmodified T cells (middle panel), the. view more
Credit: Shawn Wang, Ph.D.
Through T cell engineering, researchers at Virginia Commonwealth University Massey Cancer Center show that it s possible to arrest tumor growth for a variety of cancers and squash the spread of cancer to other tissues. This research will be published in tomorrow s print edition of
Cancer Research.
The paper builds on decades of research by study co-senior author Paul B. Fisher, M.Ph., Ph.D., a member of Massey s Cancer Biology research program, who discovered a protein called IL-24 that attacks a variety of cancers in several different ways.
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Scientists at VCU Massey Cancer Center have identified a protein that operates in tandem with a specific genetic mutation to spur lung cancer growth and could serve as a therapeutic target to treat the disease.
Mutations in the p53 gene are found in more than half of all cancers, but it remains difficult to effectively target the gene with drugs even decades after its discovery. Though previous research has shown that p53 acts as a tumor suppressor and initiates cancer cell death in its natural state, a new study led by Sumitra Deb, Ph.D., suggests that gain-of-function (GOF) mutations a type of mutation where the changed gene has an added function turn p53 into an oncogene, causing cells to replicate uncontrollably and contribute to cancer development.