5-year-old MJ and 2-year-old Zariella are a very special brother and sister pair from Centurion. They are the centre of their mom, Carmen, dad Stephan and their grandparents' lives. The children are bravely soldiering on, facing medical challenge after medical challenge.
This article looks at Johanson–Blizzard syndrome (JBS), a rare autosomal recessive condition caused by homozygous and compound heterozygous mutations in the UBR1 gene.