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NEW YORK, NY (April 29, 2021) A new study is drawing the most detailed picture yet of SARS-CoV-2 infection in the lung, revealing mechanisms that result in lethal COVID-19, and may explain long-term complications and show how COVID-19 differs from other infectious diseases.
Led by researchers at Columbia University Vagelos College of Physicians and Surgeons and Herbert Irving Comprehensive Cancer Center, the study found that in patients who died of the infection, COVID-19 unleashed a detrimental trifecta of runaway inflammation, direct destruction and impaired regeneration of lung cells involved in gas exchange, and accelerated lung scarring.
Though the study looked at lungs from patients who had died of the disease, it provides solid leads as to why survivors of severe COVID may experience long-term respiratory complications due to lung scarring.
Melanoma Resistance to Checkpoint Therapy Scrutinized with Perturb-CITE-Seq
March 1, 2021
Immune checkpoint inhibitors (ICIs), drugs that release the immune system’s “brakes,” are meant to expose cancer to the full force of the immune system’s attack. But in most cancer patients, ICIs leave the brakes engaged. To understand why this is the case and to identify ways that ICIs could succeed more often scientists based at Columbia University and the Massachusetts Institute of Technology have created a new technique to study ICI resistance (ICR).
Essentially, the technique, which is called Perturb-CITE-sequencing (or Perturb-CITE-seq), surveys the pathways that cancer cells may use to escape ICI immunotherapy. Perturb-CITE-seq is an extension of Perturb-seq, a technique that combines CRISPR-based perturbation screens and massively parallel single-cell RNA sequencing. Like Perturb-seq, Perturb-CITE-seq provides RNA readouts. In addition, however, Perturb-CITE-seq provides prote