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New Target Structure Against Corona

New Target Structure Against Corona
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Jan schlegel universitJochen bodemInstitute of virologyJan schlegelProfessor jochen bodemNorganic chemistryMarkus sauerFree state

Acid ceramidase is a SARS-CoV-2 host factor, study says

Fluoxetine, a common antidepressant, inhibits the SARS-CoV-2 coronavirus in cell cultures and in preparations from human lung tissue. This was demonstrated by researchers at Julius-Maximilians-Universität (JMU) Würzburg in the summer of 2020. However, the mechanism of this inhibition was utterly unclear, so the teams continued their research.

Jochen bodemEmily hendersonInstitute of virologyProfessor jochen bodemNorganic chemistryMarkus sauerFree stateArs cov 2

Antiviral Effect of Plant Extracts

Antiviral Effect of Plant Extracts
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Jochen bodemMaria steinkeFraunhofer translational centerResearch development innovation departmentInstitute of virologyFraunhofer institute for silicate researchRegenerative therapiesFraunhofer instituteSilicate researchDevelopment innovationEvonik operations gmbhOpen access

Researchers discover SARS-CoV-2 inhibitors

E-Mail IMAGE: with one of the newly developed inhibitors in the active centre. The individual domains of the protein are shown in different colours, the inhibitor in pink. view more Credit: © V. Namasivayam/Pharmazeutisches Institut/Uni Bonn A research team of pharmacists at the University of Bonn has discovered two families of active substances that can block the replication of the SARS-CoV-2 coronavirus. The drug candidates are able to switch off the the key enzyme of the virus, the so-called main protease. The study is based on laboratory experiments. Extensive clinical trials are still required for their further development as therapeutic drugs. The results have now been published in the journal

Nordrhein westfalenVigneshwaran namasivayamKatharina sylvesterDominik thimmGhazl al hamwiChristin vielmuthJochen bodemVittoria lopezSalahuddin mirzaThanigaimalai pillaiyarCarina lemkeAngewandte chemieRobin gedscholdMaria zyulinaPhuong vuJulian breidenbach

Scientists map direct interactions between SARS-CoV-2 RNA and human host cells

Scientists map direct interactions between SARS-CoV-2 RNA and human host cells Scientists from Würzburg and the US have charted the first global atlas of direct interactions between SARS-CoV-2 RNA and human host cells. This may provide a starting point for novel treatments. SARS-CoV-2 infections pose a global threat to human health and a formidable research challenge. One of the most urgent tasks is to gain a detailed understanding of the molecular interactions between the virus and the cells it infects. It must also be clarified, whether these interactions favour the multiplication of the virus or - on the contrary - activate defence mechanisms.

United statesUnited kingdomMathias munschauerJochen bodemEmily hendersonInfection researchInstitute of virologyBroad institute cambridgeHelmholtz instituteBroad instituteProfessor jochen bodemஒன்றுபட்டது மாநிலங்களில்ஒன்றுபட்டது கிஂக்டம்எமிலி ஹென்டர்சன்தொற்று ஆராய்ச்சிநிறுவனம் ஆஃப் வைராலஜி