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 E-Mail HERSHEY, Pa. Parkinson s disease is the second most common neurodegenerative disease and affects more than 10 million people around the world. To better understand the origins of the disease, researchers from Penn State College of Medicine and The Hebrew University of Jerusalem have developed an integrative approach, combining experimental and computational methods, to understand how individual proteins may form harmful aggregates, or groupings, that are known to contribute to the development of the disease. They said their findings could guide the development of new therapeutics to delay or even halt the progression of neurodegenerative diseases. Alpha-synuclein is a protein that helps regulate the release of neurotransmitters in the brain and is found in neurons. It exists as a single unit, but commonly joins together with other units to perform cellular functions. When too many units combine, it can lead to the formation of Lewy bodies, which are associated with neuro

Israel generalHebrew universityKhalil joronJoanna zamelNir kalismanPaz droriJiaxing chenEitan lernerNikolay dokholyanNational centerPenn state cancer instituteNational institutes of healthPenn state college of medicineTranslational science institutePassan foundationIsrael science foundation