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Intermittent theta-burst stimulation (iTBS) wasn t much help for people struggling with bipolar depression, according to a new study.
In a randomized trial of 37 adults with type I or type II bipolar disorder experiencing an acute major depressive episode, those who received iTBS didn t have any fewer depressive symptoms than those who received a sham iTBS measured by Montgomery-Asberg Depression Rating Scale (MADRS) scores (least squares mean difference between groups -1.36, 95% CI -8.92 to 6.19,
P=0.91 in favor of sham iTBS), reported Lakshmi Yatham, MBBS, MBA, of the University of British Columbia Hospital in Vancouver, and colleagues.
Only three patients in each group had a clinical response; this equated to 16% of the active iTBS group versus 17% of the sham group during the double-blind phase, the group wrote in