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New research identifies key system in C. difficile that regulates the pathogen’s virulence
Washington, D.C. – December 22, 2020 – A new study has shown that 2 genes within
Clostridium difficile, AgrB1 and AgrD1, are involved in multiple functions, including the ability of the organism to form spores, move and produce toxin. The study, published in
mBio, an open-access journal of the American Society for Microbiology, provides clues as to how researchers could manipulate
C. difficile and its ability to infect people.
“From a very basic bacteriology standpoint, it’s somewhat of a novel discovery that this system is involved in so many different events at one time,” said Jimmy Ballard, PhD, professor and chairman of the Department of Microbiology and Immunology, the University of Oklahoma Health Sciences Center, Oklahoma City, and principal investigator of the study. “Agr can be targeted with drugs and other methods to inhibit its activity and prevent the organism