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Nanoparticles Detect Brain Target Engagement

Phase two clinical trials at UT Southwestern Medical Center revealed that a suspension of gold nanocrystals taken daily by patients with multiple sclerosis (MS) and Parkinson’s disease (PD) significantly reversed deficits in metabolites linked to energy activity in the brain, resulting in functional improvements.

Lou gehrigMegan craigPeter odonnell jrBenjamin greenbergJimin renClene nanomedicinePeter sguignaUt southwestern medical centerTranslational researchResearch councilPhysician scientist training programDepartment of neurologyImaging research centerBrain instituteMedical centerAssistant professor

Gold nanoparticles reverse brain deficits in multiple sclerosis, Parkinson's

Results from phase two clinical trials at UT Southwestern Medical Center showed that a suspension of gold nanocrystals taken daily by patients with multiple scl

United statesClene nanomedicineJimin renBenjamin greenbergPeter sguignaLou gehrigPeter odonnell jrPhysician scientist training programBrain instituteResearch councilSouthwestern medical centerImaging research centerAssistant professorPetero donnellAssociate professorAdvanced imaging research center

Gold nanoparticles found to reverse brain deficits in multiple sclerosis and Parkinson's

Gold nanoparticles found to reverse brain deficits in multiple sclerosis and Parkinson's
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Clene nanomedicinePeter odonnell jrPeter sguignaJimin renLou gehrigUt southwestern medical centerBrain instituteMedical centerAssistant professorPetero donnell

7T brain scans reveal potential early indicator of Alzheimer's

E-Mail DALLAS (May 3, 2021) - Researchers from the Center for BrainHealth® at The University of Texas at Dallas are investigating a potential new early indicator of the decline toward Alzheimer s disease: measuring the energy metabolism of the living human brain using cutting-edge imaging techniques. The scientists devised a unique way to illustrate energy consumption and reserves in the brain with phosphorus magnetic resonance spectroscopy using an ultra-high-field 7 Tesla MRI scanner. Their results suggest that neurological energy metabolism might be compromised in mild cognitive impairment (MCI), the stage of decline between healthy aging and more serious disease states like dementia and Alzheimer s.

United statesSandra bond chapmanNamrata dasBarbara wallaceJeffrey spenceJimin renBrain sciencesKelly king charitable foundationUniversity of texas at dallasFox family foundationGolden rule family foundationImaging research centerDallas foundationDee wyly distinguished universityHarvard medical school mclean imaging centerUt southwestern medical center