Inflammatory bowel disease (IBD), a family of autoimmune diseases of the gut, has set researchers on a hunt to understand which microbes are responsible for launching the immune system into overdrive. Previous studies have demonstrated and pointed to gut fungus as a culprit in the inflammatory bowel disease, Crohn's disease. Now, Weill Cornell Medicine researchers report that antibody protection against harmful forms of fungi in the gut may be disrupted in some patients with Crohn’s disease.
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March 2, 2021
The Office of Academic Integration (OVPAI) has awarded $750,000 in seed grants to 10 studies ranging from refugee health and legal rights, to a vaccine treating fentanyl addiction and overdose, to pancreatic cancer and antibiotic tolerance.
This year’s awardees represent faculty collaborations across five colleges and schools, and 18 departments and divisions across the Cornell Ithaca campus and Weill Cornell Medicine and Cornell Tech in New York City.
Designed to catalyze collaborative research interactions among Cornell faculty based in Ithaca and New York City, OVPAI provides funding opportunities that foster transdisciplinary, multi-investigator programs that aim to be competitive for support from federal funders and major foundations.
February 11, 2021
The discovery of an “Achilles’ heel” in a type of gut bacteria that causes intestinal inflammation in patients with Crohn’s disease may lead to more targeted therapies for the difficult-to-treat disease, according to researchers at Weill Cornell Medicine and NewYork-Presbyterian.
In a study published Feb. 5 in Cell Host and Microbe, the investigators showed that patients with Crohn’s disease have an overabundance of a type of gut bacteria called adherent-invasive Escherichia coli (AIEC), which
promotes inflammation in the intestine. Their experiments revealed that a metabolite produced by the bacteria interacts with immune system cells in the lining of the intestine, triggering inflammation.