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IMAGE: Zhimin Gu, Ph.D., postdoctoral fellow, Children s Medical Center Research Institute at UT Southwestern (CRI), and Jian Xu Ph.D., associate professor, CRI view more
Credit: UT Southwestern Medical Center
DALLAS - April 8, 2021 - New research has uncovered a surprising role for so-called jumping genes that are a source of genetic mutations responsible for a number of human diseases. In the new study from Children s Medical Center Research Institute at UT Southwestern (CRI), scientists made the unexpected discovery that these DNA sequences, also known as transposons, can protect against certain blood cancers.
These findings, published in
Nature Genetics, led scientists to identify a new biomarker that could help predict how patients will respond to cancer therapies and find new therapeutic targets for acute myeloid leukemia (AML), the deadliest type of blood cancer in adults and children.
Jian Xu; Xiao-Ping Xia; Qiang Wang; Christopher J. Spencer; Bin He .
Abstract:
The mechanisms and processes by which subducted slab interacted with mantle
plume remain controversial, as direct observation of such interaction is
difficult to impossible. Compositional heterogeneity of large igneous
provinces (LIPs) additionally makes plume-slab interaction hard to detect.
Oxygen isotopes are sensitive enough to trace the source of magmas. Here we
provide evidence for plume-slab interaction mainly based on in situ zircon
Hf-O isotope analyses, as well as whole-rock elemental and Sr-Nd-Hf isotope
analyses, on the Late Permian and Early Triassic A-type granites on the
margin of the Emeishan LIP in SW China. These granites show typical A-type
Applying physics expertise to making smiles brighter With a background in physics and material science, Yu Zhang has joined the School of Dental Medicine to advance the way dentists restore oral health. Yu Zhang joined the Penn Dental Medicine faculty last year, bringing a wealth of expertise in physics and engineering to complement the School’s existing strengths.
In general, ceramics don’t have a reputation for being a rough-and-tumble material. Rather they seem prone to damage: Imagine a vase or decorative dish, for example, capable of shattering with an errant knock.
Yet ceramics, specifically a material called zirconium dioxide, or zirconia for short, is much stronger than those decorative objects, and has become increasingly relied upon in dentistry. Used in crowns, bridges, and other applications, the resulting products can restore function and beauty to patients’ smiles.