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Cancer Tricks Immune Cells, Immunotherapy Can Take Advantage
A paper published today in Nature shows how chemicals in the areas surrounding tumors known as the tumor microenvironment subvert the immune system and enable cancer to evade attack. These findings suggest that an existing drug could boost cancer immunotherapy.
The study was conducted by a team of scientists at the University of Pittsburgh School of Medicine and UPMC Hillman Cancer Center, led by Pitt associate professor of immunology Greg Delgoffe. By disrupting the effect of the tumor microenvironment on immune cells in mice, the researchers were able to shrink tumors, prolong survival and increase sensitivity to immunotherapy.
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IMAGE: Cancer evades the immune system by feeding the T cells that protect the tumor and starving the T cells that would attack. view more
Credit: UPMC, created with BioRender.com
PITTSBURGH, Feb. 15, 2021 - A paper published today in
Nature shows how chemicals in the areas surrounding tumors known as the tumor microenvironment subvert the immune system and enable cancer to evade attack. These findings suggest that an existing drug could boost cancer immunotherapy.
The study was conducted by a team of scientists at UPMC Hillman Cancer Center and the University of Pittsburgh School of Medicine, led by Greg Delgoffe, Ph.D., Pitt associate professor of immunology. By disrupting the effect of the tumor microenvironment on immune cells in mice, the researchers were able to shrink tumors, prolong survival and increase sensitivity to immunotherapy.
Answer ALS Launches The Data is Here Campaign to Announce the Release of the World s Largest Open Sourced ALS Data Portal
The Answer ALS Data Portal seeks to empower researchers around the globe with the data needed to finally answer ALS
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NEW ORLEANS, Jan. 8, 2021 /PRNewswire/ Answer ALS, in cooperation with the Stephen Hawking Foundation, launches The Data is Here campaign on January 8 and on what would have been the famed Theoretical Physicist s 79th birthday. The campaign features a video tribute to Stephen Hawking and his tireless efforts to solve complex universal questions, while living with ALS for over 50 years. Although he and science were unable to unravel the mystery of ALS in his lifetime, the campaign boldly states, At 21, Stephen Hawking was diagnosed with ALS. In 21, we aim to make a breakthrough in his honor. The data is here.