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Investegate |AstraZeneca PLC Announcements | AstraZeneca PLC: Calquence approved in Japan for CLL

  relapsed or refractory chronic lymphocytic leukaemia   progression after 12 months vs. 68% for comparators   AstraZeneca s Calquence (acalabrutinib), a next-generation, selective Bruton s tyrosine kinase (BTK) inhibitor, has been approved in Japan for the treatment of adult patients with relapsed or refractory chronic lymphocytic leukaemia (CLL) (including small lymphocytic lymphoma [SLL]).   The approval by the Japanese Ministry of Health, Labour and Welfare was based on positive results from the ASCEND Phase III trial and a Phase I trial in Japanese patients, showing Calquence monotherapy demonstrated a statistically significant and clinically meaningful improvement in progression-free survival (PFS) versus a standard treatment of rituximab, a monoclonal antibody, combined with the physician s choice of idelalisib, a PI3-kinase inhibitor or bendamustine, a chemotherapy.

The 100-Knot Superboat That Never Was

explored the world of MHD drive-powered superboats . Short for magnetohydrodynamic, MHD drives hoped to one day revolutionize ocean-going vessels by increasing their tops speeds to 100 knots, but the low efficiency of these experimental drives made them impractical for wide implementation. A vast shape darts beneath the polar ice flows, and is gone, as silent as a living creature, but far swifter. Clad in steel, and traveling at over 100 miles per hour, it leaves only a mist-like trail of bubbles in its wake. There are no great screws or turbines churning the water. In fact, there is no sign of any sort of propulsion system at all. Instead, the huge underwater freighter is thrust through the depths by an invisible force generated by water rushing through tubes enclosed in sponsons at the submarine s sides.

Japanese film festival kicks off at drive-in cinema

Japanese film festival kicks off at drive-in cinema
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