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High-Fat Diets Increase Colorectal Cancer Risk in Mice

High-Fat Diets Increase Colorectal Cancer Risk in Mice
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United kingdomNew south walesRonald evansPieter dorresteinAnnette atkinsFritz cayabyabSally coulterManuela raffatelluGibraan rahmanShipei xingShui zhiAnupriya tripathiChristopher liddleJian guoJustinl mccarvilleRutht yu

High-fat diet changes gut bacteria, bile acids, and increases colorectal cancer risk

The prevalence of colorectal cancer in people under the age of 50 has risen in recent decades. One suspected reason: the increasing rate of obesity and high-fat diets.

United kingdomNew south walesPieter dorresteinMichael downesRonald evansManuela raffatelluJian guoFritz cayabyabJanelle ayresShui zhiAnupriya tripathiQiyun zhuJustinl mccarvilleZhenjiang xuChristopher liddleAnnette atkins

Two Types of T Cells Implicated in Fat and Muscle Wasting during Infection

Two Types of T Cells Implicated in Fat and Muscle Wasting during Infection
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Samuel redfordJanelle ayresSystems physiology laboratorySalk institute legacySalk instituteSalk institute legacy chairSystems physiologyCell reports

Muscle loss found to aid in fighting infections

Wasting, the simultaneous loss of fat and muscle, has long been observed as a common symptom during infections. Seeking to unravel the potential benefits of this process in fighting infections, scientists at the Salk Institute, led by Professor Janelle Ayres, conducted an innovative study using mice infected with the parasite T. brucei.

Janelle ayresSamuel redfordSalk institute legacySalk instituteSystems physiology laboratoryProfessor janelle ayresCell reportsSalk institute legacy chairImmune systemT cellsLosing weightMuscle lossOncept of diet and weight loss

New understanding of wasting could lead to better treatments for infections

Although infections can present with many different symptoms, one common symptom is the loss of fat and muscle, a process called wasting.

Natalia thorupKarina sanchezSamuel redfordLily ramseyJanelle ayreJanelle ayresSalk institute legacySystems physiology laboratoryProfessor janelle ayreCell reportsSenior authorSalk institute legacy chairSystems physiologySiva karthik varanasiMuscle wasting