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Proteins play crucial role in muscle growth When a muscle grows, because its owner is still growing too or has started exercising regularly, some of the stem cells in this muscle develop into new muscle cells. The same thing happens when an injured muscle starts to heal. At the same time, however, the muscle stem cells must produce further stem cells - i.e., renew themselves - as their supply would otherwise be depleted very quickly. This requires that the cells involved in muscle growth communicate with each other. Muscle growth is regulated by the Notch signaling pathway Two years ago, a team of researchers led by Professor Carmen Birchmeier, head of the Developmental Biology/Signal Transduction Lab at the Berlin-based Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), showed that the development of stem cells into muscle cells is regulated with the help of two proteins, Hes1 and MyoD, which are produced in the progenitor cells in an oscillatory man

Max delbrJana wolfCarmen birchmeierInes lahmannYao zhangKatharina baumEmily hendersonNature communicationsDevelopmental biology signal transduction labHelmholtz associationProfessor carmen birchmeierSignal transduction labBerlin based max delbrMolecular medicineProfessor jana wolfDevelopmental biology