Page 2 - James Bonnar News Today : Breaking News, Live Updates & Top Stories | Vimarsana
Baton for world s longest relay passes through Lanarkshire on way to COP27 in Egypt
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In pictures: The lost shops from Dunfermline s High Street
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Nyrada says European patent to be granted for cholesterol-lowering drug
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Date Time
Nyrada announces to new cholesterol-lowering drug candidates
Australian preclinical drug development company Nyrada (ASX:NYR) has provided an update on the progress of its small molecule cholesterol-lowering program.
The company said a previous in vivo preclinical study showed NYX-PCSK9i reduced total cholesterol by 57 per cent without adverse side effects. It said it has now commenced a new in vivo efficacy study in the same specialised transgenic mouse model to evaluate NYX-PCSK9i in combination with a statin.
Nyrada said the study aims to determine if NYX-PCSK9i enhances the efficacy of a statin when co-administered.
It also said recent medicinal chemistry work has revealed two promising drug candidates (NYX-PCSK9i-211 and NYX-PCSK9i-212) with in vitro testing confirming they have improved potency and bioavailability compared to NYX-PCSK9i.