The Choi and Roybal labs have jointly engineered a novel therapy for solid tumors. It borrows a superpower from T cell cancers to make T cell therapies strong enough to fight skin, lung and stomach cancers.
New technique could make human T cells 100 times more potent at killing cancer cells medicalxpress.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from medicalxpress.com Daily Mail and Mail on Sunday newspapers.
Immune cells armed with a mutation first identified in cancer cells gain potency but don’t turn cancerous themselves. Immune cells armed with a mutation first identified in cancer cells gain potency but don’t turn cancerous themselves.
Scientists Harness Cancer s Strength to Combat It in Judo Move miragenews.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from miragenews.com Daily Mail and Mail on Sunday newspapers.
<p style="text-align:left">Scientists at the UC San Francisco (UCSF) and Northwestern Medicine may have found a way around the limitations of engineered T cells by borrowing a few tricks from cancer itself. </p>
<p style="text-align:left">By studying mutations in malignant T cells that cause lymphoma, they zeroed in on one that imparted exceptional potency to engineered T cells. Inserting a gene encoding this unique mutation into normal human T cells made them more than 100 times more potent at killing cancer cells without any signs of becoming toxic. </p>
<p style="text-align:left">While current immunotherapies work only against cancers of the blood and bone marrow, the T cells engineered by Northwestern and UCSF were able to kill tumors derived from skin, lung and stomach in mice. The team has already begun working toward testing this new approach in people.</p>